随着国际学术交流的日益频繁,英语听说写能力已经成为重要的基本技能。不知诸位是否也有感叹脑容量不够大的时候。医学英语词汇量大得让人挠头,拉美、印巴、日韩等各地口音令人抓狂。
《肿瘤瞭望》长期关注国内外临床肿瘤学术会议动态,采访了数百位肿瘤学专家,久经沙场而小有心得。今起,小编整理若干有代表性的采访英语与诸君分享。先用美国Cedars-Sinai医学中心Stephen J. Freedland教授纯正的美式英语打个样。
五洲四海听采访
先听为快 Listening
请先仔细听音频。
为了避免理解障碍,提示部分专业词汇如下:
mHSPC(metastatic hormone sensitive prostate cancer) 转移性激素敏感前列腺癌
mCRPC(metastatic castrate resistant prostate cancer) 转移性去势抵抗前列腺癌
ADT(androgen deprivation therapy)雄激素剥夺治疗
abiraterone 阿比特龙
(图片来源:网络)
字幕君 Subtitle
Oncology Frontier: Thank you very much for the interview with Oncology Frontier.
感谢您接受肿瘤瞭望的采访
My first question is, with the purpose of delaying the progression from mHSPC to mCRPC, what’s the strongly recommended treatment?
我的第一个问题是,为了延缓前列腺癌由mHSPC进展为mCRPC,您认为最值得推荐的治疗方案是什么?
ADT or ADT plus chemo or other combinations?
是ADT,还是ADT联合化疗,还是其他组合?
Dr. Freedland :That’s a great question in terms of what is the best management.
这是有关(前列腺癌治疗)最佳策略的一个很好的问题
We’re still seeing patients present with metastatic hormone sensitive prostate cancer.
我们仍看到患者(初诊时大部分)表现为转移性激素敏感型前列腺癌
And if you would have asked that question five years ago, we would have said hormone therapy—nothing else works.
若5年前提此问题,我们可能回答是激素治疗,(因为)没有其他有效的治疗方法
We learned three years ago that hormone therapy plus chemotherapy prolonged survival.
3年前,我们知道激素联合化疗可延长生存
And just six months ago, we learned that ADT plus abiraterone improved survival.
而6月前,我们获悉ADT联合阿比特龙可改善生存
And so now the challenge is: who should get ADT alone, who gets chemotherapy, who gets abiraterone? We don’t know the answer.
如今面临的挑战是:哪些患者适合单独ADT治疗, 哪些患者适合化疗,哪些患者适合阿比特龙治疗?答案不得而知
If you have high-volume disease—a lot of tumor—you can define it differently,
如果疾病负荷较大—比如肿瘤较多—可以有不同的定义,
you probably should get something whether it’s chemotherapy or abiraterone.
那么患者可能可能需要联合化疗或阿比特龙治疗
And it’s really up to the physician, up to the patient.
(选择什么药物)仍取决于医生和患者
Chemotherapy probably is the more toxic, initially—but it’s six cycles. So six cycles times three weeks—in eighteen weeks, you’re done.
化疗毒副作用更明显,通常需要6个周期、18周的时间即可完成治疗
And then you can always get abiraterone later.
然后可以继续长期应用阿比特龙
Abiraterone is probably a little bit better tolerated,
阿比特龙的耐受性更好
but you have to stay on the drug until you progress, which is about almost three years.
但患者需要持续用药直至肿瘤进展,通常此过程需要3年
So you want a little more toxicity for five months, or do you want less toxicity but for three years?
所以你选择毒副作用更大的5个月(化疗),还是选择毒副作用更小但需要3年疗程(阿比特龙)?
It’s really hard to decide.
选择确实很困难
划重点 Terminology
Combination 组合,联合
The best management 最佳治疗,最佳策略
Hormone/endocrine therapy 激素/内分泌治疗
Chemotherapy 化疗
Prolong/improve survival 延长/改善生存
High-volume disease/High tumor volume 肿瘤/疾病负荷大
Tolerated 可耐受的
Toxicity 毒性,毒副作用
Stay on the drug 持续用药(不考虑上下文意思就变了,继续吸毒)
Present with 呈现,表现为